Synthesis of Novel bis-1,5-Disubstituted-1H-Tetrazoles by an Efficient Catalyst-Free Ugi-Azide Repetitive Process

Molecules

Luís E. Cárdenas-Galindo²  Alejandro Islas-Jผome¹  Karla M. Colmenero-Martínez¹  Antonio Martínez-Richa¹  Rocío Gámez-Montaño¹ 

[1] Departamento de Química, División de Ciencias Naturales y Exactas, Universidad de Guanajuato, Noria Alta S/N, Col. Noria Alta, Guanajuato C.P. 36050, Gto., Mexico; E-Mails:;Departamento Química Área Ambiental, Universidad Tecnológica de Salamanca, Av. Universidad Tecnológica No. 200, Col. Ciudad Bajío, Salamanca C.P. 36750, Gto., Mexico; E-Mail:

关键词: bis-1;    5-disubstituted-1H-tetrazoles;    Ugi-azide repetitive reaction;    MW-assisted synthesis;    catalyst-free;    chelating agents;   

DOI  :  10.3390/molecules20011519

来源: mdpi

【 摘 要 】

A series of five novel bis-1,5-disubstituted-1H-tetrazoles (bis-1,5-DS-1H-T) were quickly prepared by a catalyst-free Ugi-azide repetitive process from easily accessible starting materials in excellent yields, either at room temperature (88%–95%) or using mild MW-heating conditions (80%–91%). These molecules may have a wide range of applications, such as chelating agents, organocatalysts and luminescent materials, and mainly as bioactive compounds.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.