Isolation and Assessment of the in Vitro Anti-Tumor Activity of Smenothiazole A and B, Chlorinated Thiazole-Containing Peptide/Polyketides from the Caribbean Sponge, Smenospongia aurea

Marine Drugs

Germana Esposito¹  Roberta Teta¹  Roberta Miceli²  Luca S. Ceccarelli²  Gerardo Della Sala¹  Rosa Camerlingo²  Elena Irollo²  Alfonso Mangoni¹  Giuseppe Pirozzi²  Valeria Costantino¹ 

[1] The NeaNat Group, Dipartimento di Farmacia, Università degli Studi di Napoli Federico II, Via D. Montesano 49, 80131 Napoli, Italy; E-Mails:;Department of Experimental Oncology, Istituto Nazionale Tumori Fondazione “G. Pascale”, Via M. Semmola, 80131 Napoli, Italy; E-Mails:

关键词: Smenospongia aurea;    marine natural products;    thiazole;    structure elucidation;    anti-tumor lead molecules;    smenamides;    solid tumor cell lines;    apoptosis;    MTT assays;   

DOI  :  10.3390/md13010444

来源: mdpi

【 摘 要 】

The study of the secondary metabolites contained in the organic extract of Caribbean sponge Smenospongia aurea led to the isolation of smenothiazole A (3) and B (4), hybrid peptide/polyketide compounds. Assays performed using four solid tumor cell lines showed that smenothiazoles exert a potent cytotoxic activity at nanomolar levels, with selectivity over ovarian cancer cells and a pro-apoptotic mechanism.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.