Sulfadiazine—Chitosan Conjugates and Their Polyelectrolyte Complexes with Hyaluronate Destined to the Management of Burn Wounds

Materials

Raluca Petronela Dumitriu²  Lenuta Profire³  Loredana Elena Nita²  Oana Maria Dragostin³  Nicolae Ghetu¹  Dragoș Pieptu¹  Cornelia Vasile² 

[1] “Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Medicine, Department of Plastic and Reconstructive Surgery, 16 University Street, 700115 Iasi, Romania; E-Mails:;“Petru Poni” Institute of Macromolecular Chemistry, Department of Physical Chemistry of Polymers, 41A Grigore Ghica Voda Alley, 700487 Iasi, Romania; E-Mails:;“Grigore T. Popa” University of Medicine and Pharmacy, Faculty of Pharmacy, Department of Pharmaceutical Chemistry, 16 University Street, 700115 Iasi, Romania; E-Mail:

关键词: chitosan;    hyaluronic acid;    sulfadiazine;    polyelectrolyte complex;    burn wound;   

DOI  :  10.3390/ma8010317

来源: mdpi

【 摘 要 】

In the present study polyelectrolyte complexes (PECs) based on new sulfadiazine-chitosan conjugates with sodium hyaluronate have been developed with potential use in treatment of burn wounds. The PECs were chemically characterized using Fourier Transform—Infrared Spectroscopy, Scanning Electon Microscopy and Near Infrared Chemical Imaging Technique. The swelling behavior and in vitro sulfadiazine release were also investigated. The antimicrobial activity was evaluated towards three bacterial strains: Escherichia coli, Listeria monocytogenes and Salmonella thyphymurium. The developed PECs demonstrated their antimicrobial efficiency against tested bacterial strains, the PECs containing sulfadiazine-modified chitosan being more active than PECs containing unmodified chitosan.

【 授权许可】

CC BY   
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