Prevention of Osteoporosis by Oral Administration of Phytate-Removed and Deamidated Soybean β-Conglycinin

International Journal of Molecular Sciences

Makoto Akao³  Ryusuke Abe³  Noriko Sato³  Atsuko Hasegawa-Tanigome¹  Hitoshi Kumagai² 

[1] Department of Food Business, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan; E-Mail:;Department of Food Science and Nutrition, Kyoritsu Women’s University, 2-2-1 Hitotsubashi, Chiyoda-ku, Tokyo 101-8437, Japan; E-Mail:;Department of Chemistry and Life Science, Nihon University, 1866 Kameino, Fujisawa-shi, Kanagawa 252-0880, Japan; E-Mails:

关键词: phytate removal;    deamidation;    soybean β-conglycinin;    ovariectomy;    postmenopausal osteoporosis;   

DOI  :  10.3390/ijms16012117

来源: mdpi

【 摘 要 】

Phytate-removed and deamidated soybean β-conglycinin (PrDS) prepared by ion-exchange resins was supplemented to be 4% in the diet administered to ovariectomized rats to investigate its preventive effect on osteoporosis. The apparent calcium absorption rate decreased following ovariectomy and was not replenished by oral administration of phytate-removed soybean β-conglycinin (PrS) or casein. On the other hand, administration of PrDS restored the calcium absorption rate to the same level as the sham group. Markers of bone resorption, such as serum parathyroid hormone (PTH) and urinary deoxypyridinoline (DPD), increased, and the bone mineral density and breaking stress decreased following ovariectomy. However, PrDS supplementation suppressed the changes caused by the decrease in calcium absorption from the small intestine. Therefore, PrDS supplementation shows promise for the prevention of postmenopausal osteoporosis.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.