Multidrug Efflux Pumps from Enterobacteriaceae, Vibrio cholerae and Staphylococcus aureus Bacterial Food Pathogens

International Journal of Environmental Research and Public Health

Jody L. Andersen²  Gui-Xin He³  Prathusha Kakarla²  Ranjana KC²  Sanath Kumar¹  Wazir Singh Lakra¹  Mun Mun Mukherjee²  Indrika Ranaweera²  Ugina Shrestha²  Thuy Tran³  Manuel F. Varela² 

[1] QC Laboratory, Harvest and Post-Harvest Technology Division, Central Institute of Fisheries Education (CIFE), Seven Bungalows, Versova, Andheri (W), Mumbai 400061, India; E-Mails:;Department of Biology, Eastern New Mexico University, Portales, NM 88130, USA; E-Mails:;Department of Clinical Laboratory and Nutritional Sciences, University of Massachusetts Lowell, Lowell, MA 01854, USA; E-Mails:

关键词: antimicrobial;    bacteria;    resistance;    efflux pumps;    multidrug resistance;    food pathogens;    Staphylococcus aureus;    Enterobacteriaceae;    Vibrionaceae;    infection;   

DOI  :  10.3390/ijerph120201487

来源: mdpi

【 摘 要 】

Foodborne illnesses caused by bacterial microorganisms are common worldwide and constitute a serious public health concern. In particular, microorganisms belonging to the Enterobacteriaceae and Vibrionaceae families of Gram-negative bacteria, and to the Staphylococcus genus of Gram-positive bacteria are important causative agents of food poisoning and infection in the gastrointestinal tract of humans. Recently, variants of these bacteria have developed resistance to medically important chemotherapeutic agents. Multidrug resistant Escherichia coli, Salmonella enterica, Vibrio cholerae, Enterobacter spp., and Staphylococcus aureus are becoming increasingly recalcitrant to clinical treatment in human patients. Of the various bacterial resistance mechanisms against antimicrobial agents, multidrug efflux pumps comprise a major cause of multiple drug resistance. These multidrug efflux pump systems reside in the biological membrane of the bacteria and actively extrude antimicrobial agents from bacterial cells. This review article summarizes the evolution of these bacterial drug efflux pump systems from a molecular biological standpoint and provides a framework for future work aimed at reducing the conditions that foster dissemination of these multidrug resistant causative agents through human populations.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.