A Facile Ionic Liquid Promoted Synthesis, Cholinesterase Inhibitory Activity and Molecular Modeling Study of Novel Highly Functionalized Spiropyrrolidines

Molecules

Abdulrahman I. Almansour⁵  Raju Suresh Kumar⁵  Natarajan Arumugam⁵  Alireza Basiri³  Yalda Kia⁴  Mohamed Ashraf Ali¹  Mehvish Farooq²  Vikneswaran Murugaiyah³ 

[1] Pharmacogenetic and Novel Therapeutic Institute for Research in Molecular Medicine, Universiti Sains Malaysia, Minden 11800, Malaysia; E-Mail:;Institute of Pharmaceutical Science, King’s College London, London SE1 9NH, UK; E-Mail:;School of Pharmaceutical Sciences, Universiti Sains Malaysia, Minden 11800, Malaysia; E-Mails:;School of Chemical Sciences, Universiti Sains Malaysia, Minden 11800, Malaysia; E-Mail:;Department of Chemistry, College of Science, King Saud University, P.O. Box 2455, Riyadh 11451, Saudi Arabia; E-Mails:

关键词: acetylcholinesterase (AChE);    butyrylcholinesterase (BChE);    Alzheimer’s disease (AD);    spiropyrrolidines;    ionic liquid;    molecular docking study;   

DOI  :  10.3390/molecules20022296

来源: mdpi

【 摘 要 】

A series of novel dimethoxyindanone embedded spiropyrrolidines were synthesized in ionic liquid, [bmim]Br and were evaluated for their inhibitory activities towards cholinesterases. Among the spiropyrrolidines, compound 4f exhibited the most potent activity with an IC₅₀ value of 1.57 µM against acethylcholinesterase (AChE). Molecular docking simulation for the most active compound was employed with the aim of disclosing its binding mechanism to the active site of AChE receptor.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.