Production and Characterization of Cosmetic Nanoemulsions Containing Opuntia ficus-indica (L.) Mill Extract as Moisturizing Agent

Molecules

Renato Cesar de Azevedo Ribeiro¹  Stella Maria de Andrade Gomes Barreto¹  Elissa Aarantes Ostrosky¹  Pedro Alves Rocha-Filho²  Lourena Mafra Veríssimo¹  Márcio Ferrari¹ 

[1] College of Pharmacy, Federal University of Rio Grande do Norte, Rua Gustavo Cordeiro de Farias, s/n, Petrópolis, Natal 59012-570, RN, Brazil; E-Mails:;College of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Avenida Zeferino Vaz, s/n, Monte Alegre, Ribeirão Preto 14040-903, SP, Brazil; E-Mail:

关键词: nanoemulsions;    Opuntia ficus-indica;    non-invasive methods;    emulsions;    formulation/stability;    skin barrier;   

DOI  :  10.3390/molecules20022492

来源: mdpi

【 摘 要 】

This study aimed to produce and characterize an oil in water (O/W) nanoemulsion containing Opuntia ficus-indica (L.) Mill hydroglycolic extract, as well as evaluate its preliminary and accelerated thermal stability and moisturizing efficacy. The formulations containing 0.5% of xanthan gum (FX) and 0.5% of xanthan gum and 1% of Opuntia ficus-indica MILL extract (FXE) were white, homogeneus and fluid in aspect. Both formulations were stable during preliminary and accelerated stability tests. FX and FXE presented a pH compatible to skin pH (4.5–6.0); droplet size varying from 92.2 to 233.6 nm; a polydispersion index (PDI) around 0.200 and a zeta potential from −26.71 to −47.01 mV. FXE was able to increase the water content of the stratum corneum for 5 h after application on the forearm. The O/W nanoemulsions containing 1% of Opuntia ficus-indica (L.) Mill extract presented suitable stability for at least for 60 days. Besides, this formulation was able to increase the water content of stratum corneum, showing its moisturizing efficacy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.