Toxicity of the Anti-ribosomal Lectin Ebulin f in Lungs and Intestines in Elderly Mice

Toxins

Manuel Garrosa³  Pilar Jiménez¹  Jesús Tejero¹  Patricia Cabrero¹  Damián Cordoba-Diaz²  Emiliano J. Quinto¹  Manuel J. Gayoso³  Tomás Girbés¹ 

[1] Nutrition and Food Science, Faculty of Medicine, University of Valladolid, Valladolid E-47005, Spain; E-Mails:;Pharmacy and Pharmaceutical Technology, Faculty of Pharmacy and IUFI (Institute of Industrial Pharmacy), Complutense University of Madrid, Madrid E-28040, Spain; E-Mail:;Cell Biology, Histology and Pharmacology, Faculty of Medicine and INCYL (Institute of Neurosciences of Castile and Leon), University of Valladolid, Valladolid E-47005, Spain; E-Mails:

关键词: ebulin f;    Sambucus ebulus;    ribosome-inactivating proteins;    elderly mice;    toxicity;   

DOI  :  10.3390/toxins7020367

来源: mdpi

【 摘 要 】

All parts of dwarf elder (Sambucus ebulus L.) studied so far contain a ribosome-inactivating protein with lectin activity (ribosome-inactivating lectin; RIL), known as ebulin. Green fruits contain ebulin f, the toxicity of which has been studied in six-week-old mice, where it was found that the intestines were primary targets for it when administered intraperitoneally (i.p.). We performed experiments to assess whether ebulin f administration to six- and 12-month-old mice would trigger higher toxicity than that displayed in six-week-old mice. In the present report, we present evidence indicating that the toxicological effects of ebulin f after its i.p. administration to elderly mice are exerted on the lungs and intestines by an increased rate of apoptosis. We hypothesize that the ebulin f apoptosis-promoting action together with the age-dependent high rate of apoptosis result in an increase in the lectin’s toxicity, leading to a higher lethality level.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.