Design, Synthesis and Biological Evaluation of Novel Bromophenol Derivatives Incorporating Indolin-2-One Moiety as Potential Anticancer Agents

Marine Drugs

Li-Jun Wang¹  Shuai-Yu Wang¹  Bo Jiang²  Ning Wu²  Xiang-Qian Li²  Bao-Cheng Wang²  Jiao Luo²  Meng Yang²  Shui-Hua Jin²  Da-Yong Shi¹ 

[1] Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;

关键词: bromophenol;    indolin-2-one;    anticancer;    molecular hybrid;    structure–activity relationship;   

DOI  :  10.3390/md13020806

来源: mdpi

【 摘 要 】

A series of bromophenol derivatives containing indolin-2-one moiety were designed and evaluated that for their anticancer activities against A549, Bel7402, HepG2, HeLa and HCT116 cancer cell lines using MTT assay in vitro. Among them, seven compounds (4g–4i, 5h, 6d, 7a, 7b) showed potent activity against the tested five human cancer cell lines. Wound-healing assay demonstrated that compound 4g can be used as a potent compound for inactivating invasion and metastasis by inhibiting the migration of cancer cells. The structure–activity relationships (SARs) of bromophenol derivatives had been discussed, which were useful for exploring and developing bromophenol derivatives as novel anticancer drugs.

【 授权许可】

CC BY   
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