Synthesis of a Temperature-Sensitive Matrine-Imprinted Polymer and Its Potential Application for the Selective Extraction of Matrine from Radix Sophorae Tonkinensis

International Journal of Molecular Sciences

Minjie Jiang²  Lisheng Wang²  Xu Liu²  Hua Yang²  Fan Ren²  Lizhen Gan¹  Weizhe Jiang¹ 

[1] School of Pharmaceutical, Guangxi Medical University, 22 Shuangyong Road, Nanning 530021, China; E-Mail:;School of Chemistry and Chemical Engineering, Guangxi University, 100 Daxue Road, Nanning 530004, China; E-Mails:

关键词: molecularly imprinted polymer;    N-isopropyl acrylamide;    matrine;    ultrasonic extraction;   

DOI  :  10.3390/ijms16023441

来源: mdpi

【 摘 要 】

A temperature-sensitive matrine-imprinted polymer was prepared in chloroform by free-radical cross-linking copolymerization of methacrylic acid at 60 °C in the presence of ethylene glycol dimethacrylate as the cross-linker, N-isopropyl acrylamide as the temperature-responsive monomer and matrine as the template molecule. Binding experiments and Scatchard analyses revealed that two classes of binding sites were formed on molecular imprinted polymer (MIP) at 50 °C. Additionally, the thermoresponsive MIP was tested for its application as a sorbent material for the selective separation of matrine from Chinese medicinal plant radix Sophorae tonkinensis. It was shown that the thermoresponsive MIP displayed different efficiency in clean-up and enrichments using the SPE protocol at different temperatures.

【 授权许可】

CC BY   
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