Parity and Risk of Death from Gallbladder Cancer among a Cohort of Premenopausal Parous Women in Taiwan

International Journal of Environmental Research and Public Health

Te-Fu Chan²  Chen-Hsuan Wu⁴  Hui-Fen Chiu¹  Chun-Yuh Yang³ 

[1] Department of Pharmacology, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan 1st RD, Kaohsiung 807, Taiwan; E-Mail:;Graduate Institute of Medicine, College of Medicine, Kaohsiung Medical University, 100 Shih Chuan 1st RD, Kaohsiung 807, Taiwan; E-Mail:;Department of Public Health, College of Health Sciences, Kaohsiung Medical University, 100 Shih Chuan 1st RD, Kaohsiung 807, Taiwan;Department of Obstetrics and Gynecology, Kaohsiung Chang-Gung Memorial Hospital, No.123, DA-PI Rd. Niaosng Dist., Kaohsiung 833, Taiwan; E-Mail:

关键词: gallbladder cancer;    parity;    mortality;    cohort study;    Taiwan;   

DOI  :  10.3390/ijerph120201864

来源: mdpi

【 摘 要 】

Little epidemiologic research has been done on the etiology of gallbladder cancer (GC). This cohort study was undertaken to examine whether there is an association between parity and risk of death from GC. The study cohort consisted of 1,292,462 women who had a first and singleton childbirth between 1 January 1978 and 31 December 1987. We tracked each woman from the time of their first childbirth to 31 December 2009, and their vital status was ascertained by linking records with the computerized mortality database. Cox proportional hazard regression models were used to estimate the hazard ratios (HR) of death from GC associated with parity. There were 257 GC deaths during 34,980,246 person-years of follow-up. The mortality rate of GC was 0.73 cases per 100,000 person-years. As compared with women who had given birth to only one child, the adjusted HR was 1.20 (95% CI = 0.79–1.83) for women who had two children, 1.47 (95% CI = 0.95–2.29) for women who had three children, and 1.68 (95% CI = 0.99–2.85) for women with four or more births. There was a significant increasing trend in the adjusted HRs for GC with increasing parity. The findings suggested that premenopausal women of higher parity may increase the risk of death from GC.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.