Materials | |
Evaluation of Lapatinib Powder-Entrapped Biodegradable Polymeric Microstructures Fabricated by X-Ray Lithography for a Targeted and Sustained Drug Delivery System | |
Eun-Goo Jeong1  Hyung Jung Yoo2  Byeonghwa Song2  Hwang-Phill Kim1  Sae-Won Han1  Tae-You Kim1  Dong-Il Dan Cho2  | |
[1] Cancer Research Institute, Seoul National University College of Medicine, Seoul 110-799, Korea; E-Mails:;Inter-university Semiconductor Research Center, Automation System Research Institute, School of Electrical Engineering and Computer Science, Seoul National University, Seoul 151-744, Korea; E-Mails: | |
关键词: drug delivery system (DDS); molecular targeted therapy; lapatinib; gastric cancer; sustained drug release; biodegradable polymer; polycaprolactone (PCL); | |
DOI : 10.3390/ma8020519 | |
来源: mdpi | |
【 摘 要 】
An oral medication of a molecular targeted drug, lapatinib, is taken regularly to maintain the drug concentration within the desired therapeutic levels. To alleviate the need for such cumbersome administration schedules in several drugs, advanced drug delivery systems (DDSs), which can provide time-controlled and sustained drug release, have recently received significant attention. A biodegradable synthetic polymer, such as polycaprolactone (PCL), is usually used as a carrier material for DDSs. In this paper, lapatinib powder-entrapped, PCL microstructures were fabricated with a precise X-ray lithography-based method.
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190016540ZK.pdf | 1058KB | download |