Fucoidan from Fucus vesiculosus Protects against Alcohol-Induced Liver Damage by Modulating Inflammatory Mediators in Mice and HepG2 Cells

Marine Drugs

Jung Dae Lim⁷  Sung Ryul Lee⁶  Taeseong Kim⁷  Seon-A Jang¹  Se Chan Kang¹  Hyun Jung Koo²  Eunsoo Sohn³  Jong Phil Bak⁴  Seung Namkoong⁵  Hyoung Kyu Kim⁶  In Sung Song⁶  Nari Kim⁶  Eun-Hwa Sohn⁷  Jin Han⁶ 

[1] Department of Life Science, Gachon University, Seongnam 461-701, Korea; E-Mails:;Department of Medicinal and Industrial Crops, Korea National College of Agriculture and Fisheries, Hwasung 445-760, Korea; E-Mail:;Division of Information Analysis Research, Korea Institute of Science and Technology Information, KISTI, Seoul 130-741, Korea; E-Mail:;The Clinical Center for Bio-industry, Semyung University, Jecheon, 390-711, Korea; E-Mail:;Department of Physical Therapy, Kangwon National University, Gangwon-do 245-711, Korea; E-Mail:;College of Medicine, Cardiovascular and Metabolic Disease Center and Department of Health Sciences and Technology, Graduate School of Inje University, Inje University, Busan 614-735, Korea; E-Mails:;Department of Herbal Medicine Resource, Kangwon National University, Gangwon-do 245-905, Korea; E-Mails:

关键词: fucoidan;    transforming growth factor beta 1;    cyclooxygenase-2;    alcohol;    liver;   

DOI  :  10.3390/md13021051

来源: mdpi

【 摘 要 】

Fucoidan is an l-fucose-enriched sulfated polysaccharide isolated from brown algae and marine invertebrates. In this study, we investigated the protective effect of fucoidan from Fucus vesiculosus on alcohol-induced murine liver damage. Liver injury was induced by oral administration of 25% alcohol with or without fucoidan (30 mg/kg or 60 mg/kg) for seven days. Alcohol administration increased serum aspartate aminotransferase and alanine aminotransferase levels, but these increases were suppressed by the treatment of fucoidan. Transforming growth factor beta 1 (TGF-β1), a liver fibrosis-inducing factor, was highly expressed in the alcohol-fed group and human hepatoma HepG2 cell; however, the increase in TGF-β1 expression was reduced following fucoidan administration. Treatment with fucoidan was also found to significantly reduce the production of inflammation-promoting cyclooygenase-2 and nitric oxide, while markedly increasing the expression of the hepatoprotective enzyme, hemeoxygenase-1, on murine liver and HepG2 cells. Taken together, the antifibrotic and anti-inflammatory effects of fucoidan on alcohol-induced liver damage may provide valuable insights into developing new therapeutics or interventions.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.