Isolation and Cytotoxicity Evaluation of the Chemical Constituents from Cephalantheropsis gracilis

International Journal of Molecular Sciences

Chi-Fen Chang¹  Yu-Lin Hsu²  Chao-Ying Lee³  Chia-Hua Wu³  Yang-Chang Wu³  Ta-Hsien Chuang³ 

[1] Department of Anatomy, School of Medicine, China Medical University, Taichung 40402, Taiwan; E-Mail:;Department of Chemistry, National Cheng Kung University, Tainan 70101, Taiwan; E-Mail:;School of Pharmacy, China Medical University, Taichung 40402, Taiwan; E-Mails:

关键词: Cephalantheropsis gracilis;    Orchidaceae;    quinazoline;    tryptanthrin;    indolotryptanthrin;    dihydrophenanthrene;    cytotoxicity;   

DOI  :  10.3390/ijms16023980

来源: mdpi

【 摘 要 】

Cephalantheropsis gracilis afforded five new compounds: cephalanthrin-A (1), cephalanthrin-B (2), cephathrene-A (3), cephathrene-B (4), methyl 2-(aminocarbonyl)phenylcarbamate (5), and 52 known compounds. The structures of the new compounds were determined by spectroscopic analysis. Among the compounds isolated, tryptanthrin (6), phaitanthrin A (7), cephalinone D (19), and flavanthrin (30) showed significant cytotoxicity against MCF-7, NCI-H460, and SF-268 cell lines.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.