Biomedicines | |
Anti-Differentiation Effect of Oncogenic Met Receptor in Terminally-Differentiated Myotubes | |
Valentina Sala2  Simona Gallo2  Stefano Gatti2  Elisa Vigna1  Antonio Ponzetto1  Tiziana Crepaldi2  | |
[1] Department of Oncology, Candiolo Cancer Institute—Fondazione del Piemonte per l'Oncologia (FPO) Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS), Strada Provinciale 142, Km 3.95, 10060 Candiolo, Italy; E-Mail:;Department of Oncology, University of Turin, Corso Massimo D’Azeglio 52, 10126 Turin, Italy; E-Mails: | |
关键词: HGF; Met receptor; myogenic stem cells; skeletal muscle; differentiation; proteasome; Erk1; 2 MAPK; | |
DOI : 10.3390/biomedicines3010124 | |
来源: mdpi | |
【 摘 要 】
Activation of the hepatocyte growth factor/Met receptor is involved in muscle regeneration, through promotion of proliferation and inhibition of differentiation in myogenic stem cells (MSCs). We previously described that the specific expression of an oncogenic version of the Met receptor (Tpr–Met) in terminally-differentiated skeletal muscle causes muscle wasting
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190016263ZK.pdf | 1181KB | download |