Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery

Molecules

Prabagar Balakrishnan³  Eun-Kyoung Park¹  Chung-Kil Song²  Hyun-Jeong Ko⁴  Tae-Wook Hahn⁵  Ki-Won Song¹  Hyun-Jong Cho⁴ 

[1] Department of Organic Material Science & Engineering, Pusan National University, Busan 609-735, Korea; E-Mails:;College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea; E-Mail:;College of Pharmacy, Hanyang University, Ansan 426-791, Korea;College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea; E-Mail:;College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 200-701, Korea; E-Mail:

关键词: fexofenadine hydrochloride;    nasal delivery;    thermoreversibility;    poloxamer;    carbopol;    bioavailability;   

DOI  :  10.3390/molecules20034124

来源: mdpi

【 摘 要 】

The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and drug release profile. Thermoreversibility of P407/C934P gel was demonstrated by rheological studies. The incorporation of carbopol into P407 gel also reduced the amounts of drug released from the gel formulations (p < 0.05). In vivo pharmacokinetic results of the prepared gel formulations in rabbits (at 0.5 mg/kg dose) showed that the relative bioavailability of drug from P407/C934P gel was 11.3 and 2.7-fold higher than those of drug solution and P407 gel group, respectively. These findings suggested that developed thermoreversible gels could be used as promising dosage forms to improve intranasal drug absorption.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.