Molecules | |
Carbopol-Incorporated Thermoreversible Gel for Intranasal Drug Delivery | |
Prabagar Balakrishnan3  Eun-Kyoung Park1  Chung-Kil Song2  Hyun-Jeong Ko4  Tae-Wook Hahn5  Ki-Won Song1  Hyun-Jong Cho4  | |
[1] Department of Organic Material Science & Engineering, Pusan National University, Busan 609-735, Korea; E-Mails:;College of Pharmacy and Research Institute of Pharmaceutical Sciences, Seoul National University, Seoul 151-742, Korea; E-Mail:;College of Pharmacy, Hanyang University, Ansan 426-791, Korea;College of Pharmacy, Kangwon National University, Chuncheon 200-701, Korea; E-Mail:;College of Veterinary Medicine and Institute of Veterinary Science, Kangwon National University, Chuncheon 200-701, Korea; E-Mail: | |
关键词: fexofenadine hydrochloride; nasal delivery; thermoreversibility; poloxamer; carbopol; bioavailability; | |
DOI : 10.3390/molecules20034124 | |
来源: mdpi | |
【 摘 要 】
The present study describes the preparation and evaluation of a poloxamer 407 (P407)-based thermoreversible gel using Carbopol 934P (C934P) as a mucoadhesive polymer and hydroxypropyl-β-cyclodextrin (HP-β-CD) for enhancing the aqueous solubility and intranasal absorption of fexofenadine hydrochloride (FXD HCl). The prepared gels were characterized by gelation temperature, viscoelasticity, and drug release profile. Thermoreversibility of P407/C934P gel was demonstrated by rheological studies. The incorporation of carbopol into P407 gel also reduced the amounts of drug released from the gel formulations (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190015728ZK.pdf | 966KB | download |