International Journal of Molecular Sciences | |
Tetraspanin 8-Rictor-Integrin α3 Complex Is Required for Glioma Cell Migration | |
Si-Jian Pan1  Shi-Kun Zhan2  Yi-Xin Pan2  Wei Liu2  Liu-Guan Bian1  Bomin Sun2  Qing-Fang Sun1  | |
[1] Department of Neurosurgery, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Shanghai Ruijin Second Road, Shanghai 200025, China; E-Mails:;Department of Stereotactic and Functional Neurosurgery, Rui Jin Hospital, School of Medicine, Shanghai Jiao Tong University, 197 Shanghai Ruijin Second Road, Shanghai 200025, China; E-Mails: | |
关键词: malignant glioma; tetraspanin 8; integrin α3; rictor; mTORC2; AKT and cell migration; | |
DOI : 10.3390/ijms16035363 | |
来源: mdpi | |
【 摘 要 】
The malignant glioma remains one of the most aggressive human malignancies with extremely poor prognosis. Glioma cell invasion and migration are the main causes of death. In the current study, we studied the expression and the potential functions of tetraspanin 8 (Tspan8) in malignant gliomas. We found that Tspan8 expression level is high in both malignant glioma tissues and in several human glioma cell lines, where it formed a complex integrin α3 and rictor, the latter is a key component of mammalian target of rapamycin (mTOR) complex 2 (mTORC2). Disruption of this complex, through siRNA-mediated knockdown of anyone of these three proteins, inhibited U251MG glioma cell migration
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
---|---|---|---|
RO202003190015569ZK.pdf | 1728KB | download |