Development of Advanced Macrosphelides: Potent Anticancer Agents

Molecules

Seung-Mann Paek¹  Jean Jacques¹ 

[1] College of Pharmacy and Research Institute of Pharmaceutical Sciences, Gyeongsang National University, Jinju daero, Jinju, Gyeongnam 660-701, Korea; E-Mail

关键词: macrosphelides;    medicinal chemistry;    analogs;   

DOI  :  10.3390/molecules20034430

来源: mdpi

【 摘 要 】

Synthetic approaches to macrosphelide derivatives, based on medicinal chemistry, are summarized. This review contains conventional medicinal chemistry approaches, combinatorial chemistry, fluorous tagging techniques and affinity chromatography preparation. In addition, advances in their apoptosis-inducing activities are also included.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.