Two New Phenolic Glucosides from Lagerstroemia speciosa

Molecules

Janggyoo Choi²  Jae Youl Cho⁵  Soo Jung Choi⁶  Heejin Jeon⁶  Young Dong Kim⁷  Khin Myo Htwe⁴  Young Won Chin³  Woo Shin Lee¹  Jinwoong Kim²  Kee Dong Yoon⁶ 

[1] Department of Forest Sciences, Seoul National University, Seoul 151-921, Korea; E-Mail:;College of Pharmacy and Research Institute of Pharmaceutical Science, Seoul National University, Seoul 151-742, Korea; E-Mails:;College of Pharmacy and RFIND-BKplus Team, Dongguk University-Seoul, 32 Dongguk-lo, Ilsan dong-gu, Goyang 410-820, Korea; E-Mail:;Popa mountain park, Forest Department, Kyaukpadaung Township, Mandalay Division, Myanmar; E-Mail:;Department of Genetic Engineering, Sungkyunkwan University, Suwon 440-746, Korea; E-Mail:;College of Pharmacy, The Catholic University of Korea, Bucheon 420-743, Korea; E-Mails:;Department of Life Science, Hallym University, Chuncheon 200-702, Korea; E-Mail:

关键词: Lagerstroemia speciosa;    phenolic glucoside;    inhibitory activities against nitric oxide production;   

DOI  :  10.3390/molecules20034483

来源: mdpi

【 摘 要 】

Two new phenolic glucosides, 1-O-benzyl-6-O-E-caffeoyl-β-d-glucopyranoside and 1-O-(7S,8R)-guaiacylglycerol-(6-O-E-caffeoyl)-β-d-glucopyranoside, were isolated from the aerial parts of Lagerstroemia speciosa, along with ten known compounds. The structures of the isolated compounds were determined based on 1D- and 2D-NMR, Q-TOF MS and optical rotation spectroscopic data. All of the compounds showed moderate inhibitory activities against nitric oxide production in lipopolysaccharide-treated RAW264.7 cells, with IC₅₀ values of 69.5–83.3 μM.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.