International Journal of Molecular Sciences | |
Impact of Soluble HLA-G Levels and Endometrial NK Cells in Uterine Flushing Samples from Primary and Secondary Unexplained Infertile Women | |
Roberta Rizzo1  Giuseppe Lo Monte2  Daria Bortolotti1  Angela Graziano2  Valentina Gentili1  Dario Di Luca1  Roberto Marci2  | |
[1] Department of Medical Sciences, Section of Microbiology and Genetics, University of Ferrara, 44100 Ferrara, Italy; E-Mails:;Department of Morphology, Surgery and Experimental Medicine, Section of Gynecology and Obstetrics, University of Ferrara, 44100 Ferrara, Italy; E-Mails: | |
关键词: primary infertility; secondary infertility; soluble human leukocyte antigen (sHLA-G); uterine flushing; endometrial natural killer; CD158d (KIR2DL4); | |
DOI : 10.3390/ijms16035510 | |
来源: mdpi | |
【 摘 要 】
The aim of this research was to determine the levels of human leukocyte antigen G (HLA-G) and endometrial Natural Killer ((e)NK) cell percentages in uterine flushing samples from primary and secondary infertile women. sHLA-G levels were lower in the uterine flushing samples from primary infertile women in comparison with women with secondary infertility. Lower CD56+KIR2DL4+ (e)NK cell percentages were detected in primary infertile women compared with secondary infertile women. This is the first study demonstrating that primary and secondary unexplained infertilities are characterized by different basal sHLA-G levels and CD56+KIR2DL4+ (e)NK cell percentages.
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190015488ZK.pdf | 697KB | download |