International Journal of Molecular Sciences | |
Ameliorative Effects of PACAP against Cartilage Degeneration. Morphological, Immunohistochemical and Biochemical Evidence from |
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Salvatore Giunta1  Alessandro Castorina1  Rubina Marzagalli1  Marta Anna Szychlinska1  Karin Pichler3  Ali Mobasheri2  Giuseppe Musumeci1  | |
[1] Department of Biomedical and Biotechnological Sciences, Human Anatomy and Histology Section, School of Medicine, University of Catania, Via S. Sofia 87, 95123 Catania, Italy; E-Mails:;The D-BOARD European Consortium for Biomarker Discovery, Department of Veterinary Preclinical Sciences, School of Veterinary Medicine, Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7XH, UK; E-Mail:;Department of Pediatrics, Clinic for Pediatrics I Medical University of Innsbruck, Anichstr. 35, A-6020 Innsbruck, Austria; E-Mail: | |
关键词: pituitary adenylate cyclase-activating polypeptide (PACAP); Osteoarthritis; anterior cruciate ligament transection (ACLT); immunohistochemistry; Bcl-2; BAX; caspase-3; | |
DOI : 10.3390/ijms16035922 | |
来源: mdpi | |
【 摘 要 】
Osteoarthritis (OA); the most common form of degenerative joint disease, is associated with variations in pro-inflammatory growth factor levels, inflammation and hypocellularity resulting from chondrocyte apoptosis. Pituitary adenylate cyclase-activating polypeptide (PACAP) is a neuropeptide endowed with a range of trophic effects in several cell types; including chondrocytes. However; its role in OA has not been studied. To address this issue, we investigated whether PACAP expression is affected in OA cartilage obtained from experimentally-induced OA rat models, and then studied the effects of PACAP in isolated chondrocytes exposed to IL-1β
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
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