Polyoxygenated Cembrane Diterpenoids from the Soft Coral Sarcophyton ehrenbergi

International Journal of Molecular Sciences

Shi-Yie Cheng³  Shang-Kwei Wang²  Mu-Keng Hsieh¹  Chang-Yih Duh¹ 

[1] Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan; E-Mail:;Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan; E-Mail:;Department of Life Sciences, National University of Kaohsiung, Kaohsiung 811, Taiwan; E-Mail:

关键词: polyoxygenated cembranoids;    Sarcophyton ehrenbergi;    cytotoxicity;    HCMV (human cytomegalovirus);   

DOI  :  10.3390/ijms16036140

来源: mdpi

【 摘 要 】

Five new polyoxygenated cembranoids, named (+)-1,15-epoxy-2-methoxy-12-methoxycarbonyl-11E-sarcophytoxide (1), (+)-2-epi-12-methoxycarbonyl-11E-sarcophine (2), 3,4-epoxyehrenberoxide A (3), ehrenbergol D (4) and ehrenbergol E (5), were obtained from the soft coral Sarcophyton ehrenbergi. The structures of 1–5 were established on the basis of comprehensive NMR and HR-ESI-MS analyses and by comparison with reported data in the literature. Compounds 4 and 5 showed moderate cytotoxicity against P-388 (mouse lymphocytic leukemia) cancer cell line with EC₅₀ values of 2.0 and 3.0 μM, respectively. Compound 2 exhibited slight antiviral activity against HCMV (human cytomegalovirus) with IC₅₀ values of 25.0 μg/mL.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.