New Therapies for Dedifferentiated Papillary Thyroid Cancer

International Journal of Molecular Sciences

Poupak Fallahi¹  Valeria Mazzi¹  Roberto Vita²  Silvia Martina Ferrari¹  Gabriele Materazzi³  David Galleri³  Salvatore Benvenga²  Paolo Miccoli³  Alessandro Antonelli¹ 

[1] Department of Clinical and Experimental Medicine, University of Pisa, Via Savi, 10, 56126 Pisa, Italy; E-Mails:;Department of Clinical & Experimental Medicine, Section of Endocrinology, University of Messina, Piazza Pugliatti, 1, 98122 Messina, Italy; E-Mails:;Department of Surgical, Medical, Molecular Pathology and Critical Area, University of Pisa, Via Savi, 10, 56126 Pisa, Italy; E-Mails:

关键词: dedifferentiated thyroid cancer;    radioiodine;    papillary thyroid carcinoma;    RET (REarranged during Transfection);    BRAF (B-Raf proto-oncogene;    serine/threonine kinase);    RAS (Rat Sarcoma);    vascular endothelial growth factor receptor 2;    vandetanib;    cabozantinib;    sorafenib;   

DOI  :  10.3390/ijms16036153

来源: mdpi

【 摘 要 】

The number of thyroid cancers is increasing. Standard treatment usually includes primary surgery, thyroid-stimulating hormone suppressive therapy, and ablation of the thyroid remnant with radioactive iodine (RAI). Despite the generally good prognosis of thyroid carcinoma, about 5% of patients will develop metastatic disease, which fails to respond to RAI, exhibiting a more aggressive behavior. The lack of specific, effective and well-tolerated drugs, the scarcity of data about the association of multi-targeting drugs, and the limited role of radioiodine for dedifferentiated thyroid cancer, call for further efforts in the field of new drugs development. Rearranged during transfection (RET)/papillary thyroid carcinoma gene rearrangements, BRAF (B-RAF proto-oncogene, serine/threonine kinase) gene mutations, RAS (rat sarcoma) mutations, and vascular endothelial growth factor receptor 2 angiogenesis pathways are some of the known pathways playing a crucial role in the development of thyroid cancer. Targeted novel compounds have been demonstrated to induce clinical responses and stabilization of disease. Sorafenib has been approved for differentiated thyroid cancer refractory to RAI.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.