Transcriptional Regulation of Chemokine Expression in Ovarian Cancer

Biomolecules

Bipradeb Singha²  Himavanth R. Gatla²  Ivana Vancurova¹ 

[1] Department of Biological Sciences, St. John’s University, 8000 Utopia Parkway, New York, NY 11439, USA;

关键词: chemokines;    interleukin-8;    NFκB;    ovarian cancer;    transcriptional regulation;   

DOI  :  10.3390/biom5010223

来源: mdpi

【 摘 要 】

The increased expression of pro-inflammatory and pro-angiogenic chemokines contributes to ovarian cancer progression through the induction of tumor cell proliferation, survival, angiogenesis, and metastasis. The substantial potential of these chemokines to facilitate the progression and metastasis of ovarian cancer underscores the need for their stringent transcriptional regulation. In this Review, we highlight the key mechanisms that regulate the transcription of pro-inflammatory chemokines in ovarian cancer cells, and that have important roles in controlling ovarian cancer progression. We further discuss the potential mechanisms underlying the increased chemokine expression in drug resistance, along with our perspective for future studies.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.