The Role of Hypoxia-Induced miR-210 in Cancer Progression

International Journal of Molecular Sciences

Kyvan Dang²  Kenneth A. Myers¹ 

[1] Department of Biological Sciences, University of the Sciences, 600 S. 43rd Str., Philadelphia, PA 19104, USA; E-Mail

关键词: miR-210;    hypoxia;    microRNA;    apoptosis;    angiogenesis;    cancer;   

DOI  :  10.3390/ijms16036353

来源: mdpi

【 摘 要 】

Prolonged hypoxia, the event of insufficient oxygen, is known to upregulate tumor development and growth by promoting the formation of a neoplastic environment. The recent discovery that a subset of cellular microRNAs (miRs) are upregulated during hypoxia, where they function to promote tumor development, highlights the importance of hypoxia-induced miRs as targets for continued investigation. miRs are short, non-coding transcripts involved in gene expression and regulation. Under hypoxic conditions, miR-210 becomes highly upregulated in response to hypoxia inducing factors (HIFs). HIF-1α drives miR-210’s overexpression and the resultant alteration of cellular processes, including cell cycle regulation, mitochondria function, apoptosis, angiogenesis and metastasis. Here we discuss hypoxia-induced dysregulation of miR-210 and the resultant changes in miR-210 protein targets that regulate cancer progression. Potential methods of targeting miR-210 as a therapeutic tool are also explored.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.