Synthesis of Novel Dihydropyridothienopyrimidin-4,9-dione Derivatives

Molecules

Youngjae Kim³  Minjoo Kim³  Mooseong Park³  Jinsung Tae²  Du-Jong Baek¹  Ki Duk Park³  Hyunah Choo³ 

[1] Department of Chemistry, College of Natural Sciences, Sangmyung University, Seoul 110-743, Korea; E-Mail:;Department of Biological Chemistry, University of Science and Technology, Youseong-gu, Daejeon 305-350, Korea; E-Mail:;Center for Neuro-Medicine, Korea Institute of Science and Technology, Seongbuk-gu, Seoul 136-791, Korea; E-Mails:

关键词: dihydropyridothienopyrimidin-4;    9-dione;    pyridothienopyrimidine;    successive ring formation;   

DOI  :  10.3390/molecules20035074

来源: mdpi

【 摘 要 】

A novel molecular scaffold, dihydropyridothienopyrimidin-4,9-dione, was synthesized from benzylamine or p-methoxybenzylamine in six steps involving successive ring closure to form a fused ring system composed of dihydropyridone, thiophene and pyrimidone. The pharmacological versatility of the dihydropyridothenopyrimidin-4,9-dione scaffold was demonstrated by inhibitory activity against metabotropic glutamate receptor subtype 1 (mGluR1), which shows that the title compounds can serve as an interesting scaffold for the discovery of potential bioactive molecules for the treatment of human diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.