Biomolecules | |
Seeking a Mechanism for the Toxicity of Oligomeric α-Synuclein | |
Hazel L. Roberts2  David R. Brown1  | |
[1] Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK; E-Mail | |
关键词: α-synuclein; neurodegeneration; Parkinson’s disease; aggregation; toxic oligomers; amyloid fibrils; | |
DOI : 10.3390/biom5020282 | |
来源: mdpi | |
【 摘 要 】
In a number of neurological diseases including Parkinson’s disease (PD), α‑synuclein is aberrantly folded, forming abnormal oligomers, and amyloid fibrils within nerve cells. Strong evidence exists for the toxicity of increased production and aggregation of α-synuclein
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
Files | Size | Format | View |
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RO202003190015018ZK.pdf | 155KB | download |