Formylation of Electron-Rich Aromatic Rings Mediated by Dichloromethyl Methyl Ether and TiCl4: Scope and Limitations

Molecules

Iván Ramos-Tomillero²  Marta Paradís-Bas²  Ibério de Pinho Ribeiro Moreira¹  Josep Mar໚ Bofill³  Ernesto Nicolás³  Fernando Albericio² 

[1] Department of Physical Chemistry, University of Barcelona, Barcelona 08028, Spain; E-Mail:;Institute for Research in Biomedicine (IRB Barcelona), Barcelona 08028, Spain; E-Mails:;Deparment of Organic Chemistry, University of Barcelona, Barcelona 08028, Spain; E-Mail:

关键词: formylation;    TiCl₄;    aromatic rings;    aldehydes;    dichloromethyl methyl ether;   

DOI  :  10.3390/molecules20045409

来源: mdpi

【 摘 要 】

Here the aromatic formylation mediated by TiCl₄ and dichloromethyl methyl ether previously described by our group has been explored for a wide range of aromatic rings, including phenols, methoxy- and methylbenzenes, as an excellent way to produce aromatic aldehydes. Here we determine that the regioselectivity of this process is highly promoted by the coordination between the atoms present in the aromatic moiety and those in the metal core.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.