Anti-Inflammatory Effect of Streptochlorin via TRIF-Dependent Signaling Pathways in Cellular and Mouse Models

International Journal of Molecular Sciences

Do-Wan Shim³  Hee Jae Shin²  Ji-Won Han³  Woo-Young Shin³  Xiao Sun³  Eun-Jeong Shim³  Tack-Joong Kim¹  Tae-Bong Kang³  Kwang-Ho Lee³ 

[1] Division of Biological Science and Technology, Yonsei University, Wonju 222-710, Korea; E-Mail:;Marine Natural Products Chemistry Laboratory, Korea Institute of Ocean Science & Technology, 787 Haeanro, Ansan 426-744, Korea; E-Mail:;Department of Biotechnology, College of Biomedical and Health Science, Konkuk University, Chungju 380-150, Korea; E-Mails:

关键词: streptochlorin;    LPS;    anti-inflammation;    TRIF;    ALI;   

DOI  :  10.3390/ijms16046902

来源: mdpi

【 摘 要 】

Streptochlorin, a small compound derived from marine actinomycete, has been shown to have anti-angiogenic, anti-tumor, and anti-allergic activities. However, the anti-inflammatory effects and underlying mechanisms have not yet been reported. In the present study, we investigated the effect of streptochlorin on lipopolysaccharide (LPS)-induced inflammatory responses in vitro and in vivo. Streptochlorin attenuated the production of proinflammatory mediators such as nitric oxide, cyclooxygenase-2, pro-interleukin (IL)-1β, and IL-6 in LPS-stimulated RAW264.7 cells through inhibition of the Toll/interleukin-1 receptor (TIR)-domain-containing adapter-inducing interferon-β (TRIF)-dependent signaling pathway. Furthermore, streptochlorin suppressed the infiltration of immune cells such as neutrophils into the lung and proinflammatory cytokine production such as IL-6 and TNF-α in broncho-alveolar lavage fluid (BALF) in the LPS-induced acute lung injury (ALI) mouse model. Streptochlorin has potent anti-inflammatory effects through regulating TRIF-dependent signaling pathways, suggesting that streptochlorin may provide a valuable therapeutic strategy in treating various inflammatory diseases.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.