Developing Universal Influenza Vaccines: Hitting the Nail, Not Just on the Head

Vaccines

Lidewij C. M. Wiersma²  Guus F. Rimmelzwaan¹  Rory D. de Vries² 

[1] Department of Viroscience, Erasmus Medical Center, P.O. Box 2040, 3000 CA Rotterdam, The Netherlands;

关键词: influenza;    universal vaccine;    MVA;   

DOI  :  10.3390/vaccines3020239

来源: mdpi

【 摘 要 】

Influenza viruses have a huge impact on public health. Current influenza vaccines need to be updated annually and protect poorly against antigenic drift variants or novel emerging subtypes. Vaccination against influenza can be improved in two important ways, either by inducing more broadly protective immune responses or by decreasing the time of vaccine production, which is relevant especially during a pandemic outbreak. In this review, we outline the current efforts to develop so-called “universal influenza vaccines”, describing antigens that may induce broadly protective immunity and novel vaccine production platforms that facilitate timely availability of vaccines.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.