An Analysis of the Influence of Selected Genetic and Hormonal Factors on the Occurrence of Depressive Symptoms in Late-Reproductive-Age Women

International Journal of Environmental Research and Public Health

Anna Jurczak¹  Małgorzata Szkup¹  Agnieszka Samochowiec⁵  Anna Grzywacz³  Jerzy Samochowiec³  Beata Karakiewicz²  Barbara Dołęgowska⁴  El់ieta Grochans⁶ 

[1] Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland; E-Mails:;Public Health Department, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland; E-Mail:;Department of Psychiatry, Pomeranian Medical University in Szczecin, Broniewskiego Str. 26, 71-460 Szczecin, Poland; E-Mails:;Laboratory of Stem Cell Physiology and Biochemistry, Division and Department of Physiology, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland; E-Mail:;Department of Clinical Psychology, Institute of Psychology, University of Szczecin, ul. Krakowska 71–79, 71-017 Szczecin, Poland; E-Mail:;Department of Nursing, Pomeranian Medical University in Szczecin, Żołnierska Str. 48, 71-210 Szczecin, Poland

关键词: polymorphism;    AMH;    FSH;    late reproductive period;    depressive symptoms;    5-HTTLPR;    MAO-A;   

DOI  :  10.3390/ijerph120403547

来源: mdpi

【 摘 要 】

Background: The aim of this study was to analyze the influence of genetic and hormonal factors on incidences of depressive symptoms in late-reproductive-age women. Methods: The study was performed using the Beck Depression Inventory, the PCR, and genetic tests of 347 healthy late-reproductive-age Polish women. Results: The relationship between the level of anti-Müllerian hormone (AMH) and depressive symptoms was not statistically significant (p > 0.05). Increases in age and FSH levels were accompanied by a decrease in AMH level in a significant way (p < 0.05). There were no statistically significant relationships between the distribution of genotypes and the frequency of alleles of the investigated polymorphisms and depressive symptoms according to the Beck Depression Inventory. Conclusions: (1) The presence of the s/s genotype of the 5-HTTLPR polymorphism in the serotonin transporter promoter region and the 3/3 genotype of the 30-bp VNTR polymorphism in the monoamine oxidase A promoter region does not contribute to the development of depressive symptoms in late-reproductive-age women. (2) A relationship between the level of anti-Müllerian hormone and depressive symptoms was not confirmed in the group of healthy late-reproductive-age women. (3) AMH level correlates negatively with FSH level and age, which confirms that AMH can be regarded as a factor reflecting the ovarian reserve.

【 授权许可】

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.