期刊论文详细信息
Brain Sciences
Autism Spectrum Disorder (ASD) and Fragile X Syndrome (FXS): Two Overlapping Disorders Reviewed through Electroencephalography—What Can be Interpreted from the Available Information?
Niamh Mc Devitt1  Louise Gallagher1  Richard B. Reilly1 
[1] School of Medicine, Trinity College, the University of Dublin, Dublin, Ireland; E-Mails:
关键词: autism spectrum disorders;    Fragile X Syndrome;    electroencephalography;    Event Related Potentials;    resting state EEG;   
DOI  :  10.3390/brainsci5020092
来源: mdpi
PDF
【 摘 要 】

Autism Spectrum Disorder (ASD) and Fragile X syndrome (FXS) are neurodevelopmental disorders with different but potentially related neurobiological underpinnings, which exhibit significant overlap in their behavioural symptoms. FXS is a neurogenetic disorder of known cause whereas ASD is a complex genetic disorder, with both rare and common genetic risk factors and likely genetic and environmental interaction effects. A comparison of the phenotypic presentation of the two disorders may highlight those symptoms that are more likely to be under direct genetic control, for example in FXS as opposed to shared symptoms that are likely to be under the control of multiple mechanisms. This review is focused on the application and analysis of electroencephalography data (EEG) in ASD and FXS. Specifically, Event Related Potentials (ERP) and resting state studies (rEEG) studies investigating ASD and FXS cohorts are compared. This review explores the electrophysiological similarities and differences between the two disorders in addition to the potentially associated neurobiological mechanisms at play. A series of pertinent research questions which are suggested in the literature are also posed within the review.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.

【 预 览 】
附件列表
Files Size Format View
RO202003190014793ZK.pdf 178KB PDF download
  文献评价指标  
  下载次数:9次 浏览次数:34次