Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes

Insects

Joy Kean²  Stephanie M. Rainey²  Melanie McFarlane²  Claire L. Donald²  Esther Schnettler²  Alain Kohl¹  Emilie Pondeville¹ 

[1] MRC-University of Glasgow Centre for Virus Research, Glasgow, G61 1QH, Scotland, UK;

关键词: arbovirus;    Aedes;    vector control;    vector competence;    antiviral defences;    mosquito engineering;    bacteria;    insect-specific viruses;    paratransgenesis;   

DOI  :  10.3390/insects6010236

来源: mdpi

【 摘 要 】

Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of biological approaches, both natural or engineered, to limit mosquito vector competence for arboviruses. The study of mosquito antiviral immunity has led to the identification of a number of host response mechanisms and proteins that are required to control arbovirus replication in mosquitoes, though more factors influencing vector competence are likely to be discovered. We will discuss key aspects of these pathways as targets either for selection of naturally resistant mosquito populations or for mosquito genetic manipulation. Moreover, we will consider the use of endosymbiotic bacteria such as Wolbachia, which in some cases have proven to be remarkably efficient in disrupting arbovirus transmission by mosquitoes, but also the use of naturally occurring insect-specific viruses that may interfere with arboviruses in mosquito vectors. Finally, we will discuss the use of paratransgenesis as well as entomopathogenic fungi, which are also proposed strategies to control vector competence.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.