Metabolites | |
Systemic Metabolomic Changes in Blood Samples of Lung Cancer Patients Identified by Gas Chromatography Time-of-Flight Mass Spectrometry | |
Suzanne Miyamoto5  Sandra L. Taylor4  Dinesh K. Barupal3  Ayumu Taguchi2  Gert Wohlgemuth3  William R. Wikoff3  Ken Y. Yoneda1  David R. Gandara5  Samir M. Hanash2  Kyoungmi Kim4  Oliver Fiehn3  | |
[1] Division of Pulmonary Medicine, Department of Internal Medicine, UC Davis Medical Center, Sacramento, CA 95817, USA; E-Mail:;The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030, USA; E-Mails:;Genome Center, UC Davis, 451 Health Sciences Drive, University of California, Davis, CA 95616, USA; E-Mails:;Division of Biostatistics, Department of Public Health Sciences, UC Davis School of Medicine, One Shields Avenue, Med Sci 1-C, Davis, CA 95616, USA; E-Mails:;Division of Hematology/Oncology, UC Davis Cancer Center, 4501 X Street, Room 3016, Sacramento, CA 95817, USA; E-Mail: | |
关键词: metabolomic; lung cancer; mass spectrometry; blood; | |
DOI : 10.3390/metabo5020192 | |
来源: mdpi | |
【 摘 要 】
Lung cancer is a leading cause of cancer deaths worldwide. Metabolic alterations in tumor cells coupled with systemic indicators of the host response to tumor development have the potential to yield blood profiles with clinical utility for diagnosis and monitoring of treatment. We report results from two separate studies using gas chromatography time-of-flight mass spectrometry (GC-TOF MS) to profile metabolites in human blood samples that significantly differ from non-small cell lung cancer (NSCLC) adenocarcinoma and other lung cancer cases. Metabolomic analysis of blood samples from the two studies yielded a total of 437 metabolites, of which 148 were identified as known compounds and 289 identified as unknown compounds. Differential analysis identified 15 known metabolites in one study and 18 in a second study that were statistically different (
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190014519ZK.pdf | 1651KB | download |