Synthesis of Spongy-Like Mesoporous Hydroxyapatite from Raw Waste Eggshells for Enhanced Dissolution of Ibuprofen Loaded via Supercritical CO2

International Journal of Molecular Sciences

Abdul-Rauf Ibrahim¹  Xiangyun Li¹  Yulan Zhou²  Yan Huang²  Wenwen Chen²  Hongtao Wang²  Jun Li¹ 

[1] Department of Chemical and Biochemical Engineering, College of Chemistry and Chemical Engineering, National Engineering Laboratory for Green Chemical Productions of Alcohols, Ethers and Esters, Xiamen University, Xiamen 361005, China;

关键词: hydroxyapatite;    waste eggshell;    ibuprofen;    drug delivery;    supercritical loading;   

DOI  :  10.3390/ijms16047960

来源: mdpi

【 摘 要 】

The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems) is vital since high-purity synthetic calcium sources are expensive. In this work, pure and mesoporous HAp nanopowder with large pore volume (1.4cm³/g) and surface area (284.1m²/g) was produced from raw eggshells at room temperature using a simple two-step procedure. The control of precursor droplets could stabilize the pH value of the reaction solution, because of the size of the needle (of the syringe pump used for precursor additions) leading to production of HAp with high surface area and pore size. The as-produced HAp revealed high ibuprofen (as a model drug) loading (1.38g/g HAp), enhanced dissolution and controllable release of the drug via solute-saturated supercritical carbon dioxide.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.