International Journal of Molecular Sciences | |
Expression of the Aryl Hydrocarbon Receptor in Growth Plate Cartilage and the Impact of Its Local Modulation on Longitudinal Bone Growth | |
Therése Cedervall2  Pia Monica Lind1  Lars Sävendahl2  | |
[1] Department of Medical Sciences, Occupational and Environmental Medicine, Uppsala University Hospital, 751 85 Uppsala, Sweden; E-Mail:;Department of Women’s and Children’s Health, Pediatric Endocrinology Unit, Astrid Lindgren Children’s Hospital, Q2:08, Karolinska University Hospital Solna, S-171 76 Stockholm, Sweden; E-Mail: | |
关键词: AhR (aryl hydrocarbon receptor); epiphyseal growth plate; dioxin; alpha-naphthoflavone; chondrocyte; bone growth; | |
DOI : 10.3390/ijms16048059 | |
来源: mdpi | |
【 摘 要 】
Although dioxin has been reported to impair bone growth in both humans and animals, the underlying mechanisms have not been clarified. We conducted this study to rule out if dioxin may directly target the growth plate, via local modulation of the aryl hydrocarbon receptor
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190014445ZK.pdf | 1837KB | download |