Resveratrol Protects against Methylglyoxal-Induced Hyperglycemia and Pancreatic Damage In Vivo

Nutrients

An-Sheng Cheng¹  Yu-Hsiang Cheng²  Chi-Ying Lee¹  Chin-Yuan Chung¹ 

[1]Department of Medicinal Plant Development, Yupintang Traditional Chinese Medicine Foundation, 2F., No. 398, Zengzi Rd., Zuoying District, Kaohsiung City 813, Taiwan

[2] E-Mails:

[3]Department of Science, University of Auckland, 23 Symonds Street, Auckland 1142, New Zealand

[4] E-Mail:

关键词: resveratrol;    methylglyoxal;    nuclear factor erythroid 2-related factor 2;    retinoic acid;    diabetes;   

DOI  :  10.3390/nu7042850

来源: mdpi

【 摘 要 】

Methylglyoxal (MG) has been found to cause inflammation and insulin resistance in vitro and in vivo in recent studies. Resveratrol has been proposed as an effective treatment that helps lower the risk of developing complications of diabetes. To study the significance of glycosylation-related stress on the pathology of diabetes, the effects of resveratrol were examined in a mouse model of diabetes induced by MG. Resveratrol was given via oral gavage in MG-treated mice, and diabetes-related tests and markers were assessed using biochemical and immunohistochemical analyses. Treatment with resveratrol markedly improved blood glucose level from the oral glucose tolerance test and promoted nuclear factor erythroid 2-related factor-2 (Nrf2) phosphorylation (p < 0.05) in the pancreas of MG-treated mice. However, these effects were abolished by retinoic acid, Nrf2 inhibitor, in resveratrol and retinoic acid-treated and MG-induced mice. These findings support that resveratrol may be useful in the treatment of type-2 diabetes by protecting against pancreatic cell dysfunction.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.