International Journal of Molecular Sciences | |
Role of Glucokinase in the Subcellular Localization of Glucokinase Regulatory Protein | |
Ling Jin2  Tingting Guo2  Zhixin Li4  Zhen Lei1  Hui Li2  Yiqing Mao2  Xi Wang2  Na Zhou2  Yizhuang Zhang2  Ruobi Hu2  Xuehui Zhang2  Gang Niu3  David M. Irwin2  Huanran Tan2  | |
[1] Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China; E-Mail:;Department of Pharmacology, Peking University, Health Science Center, Beijing 100191, China; E-Mails:;Beijing N&N Genetech Company, Beijing 100082, China;Department of Integrated Traditional Chinese and Western Medicine, Peking University, Health Science Center, Beijing 100191, China; E-Mail: | |
关键词: protein–protein interaction; glucokinase regulatory protein; glucokinase; sub-cellular localization; glucose metabolism; | |
DOI : 10.3390/ijms16047377 | |
来源: mdpi | |
【 摘 要 】
Glucokinase (GCK) is the rate-limiting enzyme of liver glucose metabolism. Through protein-protein interactions, glucokinase regulatory protein (GCKR) post-transcriptionally regulates GCK function in the liver, and causes its nuclear localization. However the role of GCK in regulating GCKR localization is unknown. In the present study, using
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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