Meta-Analysis of the Association between Vitamin D and Autoimmune Thyroid Disease

Nutrients

Jiying Wang¹  Shishi Lv¹  Guo Chen¹  Chenlin Gao¹  Jianhua He¹  Haihua Zhong¹ 

[1] Department of Endocrinology and Metabolism, Affiliated Hospital of Luzhou Medical College, Luzhou 646000, China;

关键词: vitamin D;    autoimmune thyroid disease;    Graves’ disease;    Hashimoto thyroiditis;    meta-analysis;   

DOI  :  10.3390/nu7042485

来源: mdpi

【 摘 要 】

Although emerging evidence suggests that low levels of vitamin D may contribute to the development of autoimmune disease, the relationship between vitamin D reduction and autoimmune thyroid disease (AITD), which includes Graves’ disease (GD) and Hashimoto thyroiditis (HT), is still controversial. The aim was to evaluate the association between vitamin D levels and AITD through systematic literature review. We identified all studies that assessed the association between vitamin D and AITD from PubMed, Embase, CENTRAL, and China National Knowledge Infrastructure (CNKI) databases. We included studies that compared vitamin D levels between AITD cases and controls as well as those that measured the odds of vitamin D deficiency by AITD status. We combined the standardized mean differences (SMD) or the odds ratios (OR) in a random effects model. Twenty case-control studies provided data for a quantitative meta-analysis. Compared to controls, AITD patients had lower levels of 25(OH)D (SMD: −0.99, 95% CI: −1.31, −0.66) and were more likely to be deficient in 25(OH)D (OR 2.99, 95% CI: 1.88, 4.74). Furthermore, subgroup analyses result showed that GD and HT patients also had lower 25(OH)D levels and were more likely to have a 25(OH)D deficiency, suggesting that low levels of serum 25(OH)D was related to AITD.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.