Coupling of Petri Net Models of the Mycobacterial Infection Process and Innate Immune Response

Computation

Rafael V. Carvalho²  Jeroen van den Heuvel²  Jetty Kleijn²  Fons J. Verbeek¹  Filippo Castiglione² 

[1] Leiden Institute of Advanced Computer Science, Leiden University, Niels Bohrweg 1, 2333CA Leiden, The Netherlands;

关键词: immune system modeling;    petri net;    3D visualization;   

DOI  :  10.3390/computation3020150

来源: mdpi

【 摘 要 】

Computational and mathematical modeling is important in support of a better understanding of complex behavior in biology. For the investigation of biological systems, researchers have used computers to construct, verify, and validate models that describe the mechanisms behind biological processes in multi-scale representations. In this paper we combine Petri net models that represent the mycobacterial infection process and innate immune response at various levels of organization, from molecular interaction to granuloma dissemination. In addition to the conventional graphical representation of the Petri net, the outcome of the model is projected onto a 3D model representing the zebrafish embryo. In this manner we provide a visualization of the process in a simulation framework that portrays the infection in the living system.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.