The Potential of Chitosan and Its Derivatives in Prevention and Treatment of Age-Related Diseases

Marine Drugs

Garry Kerch¹ 

[1] Department of Materials Science and Applied Chemistry, Riga Technical University, Azenes 14/24, Riga, LV-1048, Latvia; E-Mail

关键词: chitosan;    chitooligosacharides;    age-related diseases;    protein conformations;   

DOI  :  10.3390/md13042158

来源: mdpi

【 摘 要 】

Age-related, diet-related and protein conformational diseases, such as atherosclerosis, diabetes mellitus, cancer, hypercholesterolemia, cardiovascular and neurodegenerative diseases are common in the elderly population. The potential of chitosan, chitooligosaccharides and their derivatives in prevention and treatment of age-related dysfunctions is reviewed and discussed in this paper. The influence of oxidative stress, low density lipoprotein oxidation, increase of tissue stiffness, protein conformational changes, aging-associated chronic inflammation and their pathobiological significance have been considered. The chitosan-based functional food also has been reviewed.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.