Viruses | |
Enhancement of Herpes Simplex Virus (HSV) Infection by Seminal Plasma and Semen Amyloids Implicates a New Target for the Prevention of HSV Infection | |
Lilith Torres2  Tatiana Ortiz2  Qiyi Tang1  | |
[1] Department of Microbiology, College of Medicine, Howard University, Seeley Mudd Building, Room 315, 520 W Street, NW, Washington, DC 20059, USA; | |
关键词: herpesvirus; herpes simplex virus (HSV); semen; SEVI (semen-derived enhancer of viral infection) and SEM (semenogelin) amyloids; sexual transmission; | |
DOI : 10.3390/v7042057 | |
来源: mdpi | |
【 摘 要 】
Human herpesviruses cause different infectious diseases, resulting in world-wide health problems. Sexual transmission is a major route for the spread of both herpes simplex virus-1 (HSV-1) and -2. Semen plays an important role in carrying the viral particle that invades the vaginal or rectal mucosa and, thereby, initiates viral replication. Previously, we demonstrated that the amyloid fibrils semenogelin (SEM) and semen-derived enhancer of viral infection (SEVI), and seminal plasma (SP) augment cytomegalovirus infection (Tang
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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