Molecules | |
Synthesis, Anti-Tumor and Anti-Angiogenic Activity Evaluations of Asiatic Acid Amino Acid Derivatives | |
Yue Jing2  Gang Wang2  Ying Ge2  Minjie Xu2  Zhunan Gong1  | |
[1]Center for New Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing 210023, China | |
关键词: asiatic acid; amino acid derivatives; anti-tumor activity; anti-angiogenic effect; stability; HPLC analysis; | |
DOI : 10.3390/molecules20047309 | |
来源: mdpi | |
【 摘 要 】
Fifteen semi-synthetic derivatives of asiatic acid (AA) have been synthesized and evaluated for their biological activities. The successful modification of these compounds at the C-2, C-3, C-23 and C-28 positions was confirmed using NMR, MS and IR spectra. Further, their anti-tumor effects were evaluated
【 授权许可】
CC BY
© 2015 by the authors; licensee MDPI, Basel, Switzerland.
【 预 览 】
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RO202003190013607ZK.pdf | 1662KB | download |