Mesenchymal Stem Cells and Induced Pluripotent Stem Cells as Therapies for Multiple Sclerosis

International Journal of Molecular Sciences

Juan Xiao²  Rongbing Yang¹  Sangita Biswas³  Xin Qin²  Min Zhang²  Wenbin Deng² 

[1] Department of Biological Treatment, Handan Central Hospital, Handan 056001, China; E-Mail:;Medical College, Hubei University of Arts and Science, Xiangyang 441053, China; E-Mails:;Department of Biochemistry and Molecular Medicine, School of Medicine, University of California, Davis, CA 95817, USA; E-Mail:

关键词: mesenchymal stem cells;    induced pluripotent stem cells;    neural stem cell;    multiple sclerosis;   

DOI  :  10.3390/ijms16059283

来源: mdpi

【 摘 要 】

Multiple sclerosis (MS) is a chronic, autoimmune, inflammatory demyelinating disorder of the central nervous system that leads to permanent neurological deficits. Current MS treatment regimens are insufficient to treat the irreversible neurological disabilities. Tremendous progress in the experimental and clinical applications of cell-based therapies has recognized stem cells as potential candidates for regenerative therapy for many neurodegenerative disorders including MS. Mesenchymal stem cells (MSC) and induced pluripotent stem cell (iPSCs) derived precursor cells can modulate the autoimmune response in the central nervous system (CNS) and promote endogenous remyelination and repair process in animal models. This review highlights studies involving the immunomodulatory and regenerative effects of mesenchymal stem cells and iPSCs derived cells in animal models, and their translation into immunomodulatory and neuroregenerative treatment strategies for MS.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.