Product Development Studies on Sonocrystallized Curcumin for the Treatment of Gastric Cancer

Pharmaceutics

Mohammad Ashif Khan²  Nida Akhtar²  Vijay Sharma²  Kamla Pathak¹ 

[1] Department of Pharmaceutics, Rajiv Academy for Pharmacy, N.H. #2, Delhi Mathura Road, P.O. Chhattikara, Mathura-281001, India;

关键词: curcumin;    melt sonocrystallization;    spectral characterization;    in vitro cytotoxicity;    gastroretentive floating tablet;   

DOI  :  10.3390/pharmaceutics7020043

来源: mdpi

【 摘 要 】

Curcumin suffers from the limitation of poor solubility and low dissolution that can lead to limited applications. The investigation was aimed to substantiate the potentiality of melt sonocrystallized gastroretentive tablets of curcumin. Melt sonocrystallized curcumin (MSC CMN) was developed and its therapeutic potential was validated by in vitro cytotoxicity studies against Human oral cancer cell line KB. MSC curcumin was then formulated as floating tablet and evaluated. MSC form of CMN exhibited 2.36-fold and 2.40-fold solubility enhancement in distilled water and phosphate buffer, pH 4.5, respectively, better flow properties and intrinsic dissolution rate (0.242 ± 1.42 and 0.195 ± 1.26 mg/cm²/min) in comparison to its original form. The GI₅₀ value of MSC CMN was found to be less than 10, specifying inhibition of growth more effectively at its least concentration by 50%. The gastroretentive-floating tablet (Formulation F4) displayed controlled drug release (96.22% ± 1.43%) for over 12 h. The present study revealed melt sonocrystallization can be used to produce particles with superior biopharmaceutical properties without the use of organic solvents or the addition of other excipients, and amenable to formulation in to a pharmaceutical dosage form.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.