Novel Adociaquinone Derivatives from the Indonesian Sponge Xestospongia sp.

Marine Drugs

Fei He¹  Linh H. Mai¹  Arlette Longeon¹  Brent R. Copp²  Nadège Loaຼ³  Amandine Bescond³  Laurent Meijer³  Marie-Lise Bourguet-Kondracki¹ 

[1] Laboratoire Molécules de Communication et Adaptation des Micro-organismes, CNRS/MNHN 7245, Muséum National d’Histoire Naturelle, 57 rue Cuvier (C.P. 54), 75005 Paris, France; E-Mails:;School of Chemical Sciences, University of Auckland, Private Bag 92019, Auckland 1142, New Zealand; E-Mail:;ManRos Therapeutics, Perharidy Research Center, 29680 Roscoff, France; E-Mails:

关键词: kinase inhibitor;    adociaquinone;    xestoadociaquinone;    14-carboxy-xestoquinol sulfate;    xestoadociaminal;    Xestospongia sp.;   

DOI  :  10.3390/md13052617

来源: mdpi

【 摘 要 】

Seven new adociaquinone derivatives, xestoadociaquinones A (1a), B (1b), 14-carboxy-xestoquinol sulfate (2) and xestoadociaminals A–D (3a, 3c, 4a, 4c), together with seven known compounds (5–11) were isolated from an Indonesian marine sponge Xestospongia sp. Their structures were elucidated by extensive 1D and 2D NMR and mass spectrometric data. All the compounds were evaluated for their potential inhibitory activity against eight different protein kinases involved in cell proliferation, cancer, diabetes and neurodegenerative disorders as well as for their antioxidant and antibacterial activities.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.