Background: College students’ mental health problems include depression, anxiety, panic disorders, phobias and obsessive compulsive thoughts. Aims: To investigate Greek college students’ psychopathology. Methods: During the initial evaluation, 638 college students were assessed through the following psychometric questionnaires: (a) Eysenck Personality Questionnaire (EPQ); (b) The Symptom Checklist-90 (SCL-90); (c) The Beck Depression Inventory (BDI); (d) State-Trait Anxiety Inventory (STAI). Results: State anxiety and trait anxiety were correlated, to a statistically significant degree, with the family status of the students (p = 0.024) and the past visits to the psychiatrist (p = 0.039) respectively. The subscale of psychoticism is significantly related with the students’ origin, school, family status and semester. The subscale of neuroticism is significantly related with the students’ school. The subscale of extraversion is significantly related with the students’ family psychiatric history. Students, whose place of origin is Attica, have on average higher scores in somatization, phobic anxiety and paranoid ideation than the other students. Students from abroad have, on average, higher scores in interpersonal sensitivity and psychoticism than students who hail from other parts of Greece. The majority of the students (79.7%) do not suffer from depression, according to the Beck’s depression inventory scale. Conclusions: Anxiety, somatization, personality traits and depression are related with the students’ college life.