Taxane-Induced Peripheral Neurotoxicity

Toxics

Roser Velasco¹  Jordi Bruna¹ 

[1] Unit of Neuro-Oncology, Hospital Universitari de Bellvitge-ICO Duran i Reynals, 08907 L´Hospitalet de Llobregat, Barcelona, Spain; E-Mail:

关键词: taxane;    paclitaxel;    docetaxel;    nab-paclitaxel;    cabazitaxel;    chemotherapy-induced peripheral neuropathy;    neurotoxicity;    peripheral neuropathy;    taxane-induced peripheral neuropathy;   

DOI  :  10.3390/toxics3020152

来源: mdpi

【 摘 要 】

Taxane-derived agents are chemotherapy drugs widely employed in cancer treatment. Among them, paclitaxel and docetaxel are most commonly administered, but newer formulations are being investigated. Taxane antineoplastic activity is mainly based on the ability of the drugs to promote microtubule assembly, leading to mitotic arrest and apoptosis in cancer cells. Peripheral neurotoxicity is the major non-hematological adverse effect of taxane, often manifested as painful neuropathy experienced during treatment, and it is sometimes irreversible. Unfortunately, taxane-induced neurotoxicity is an uncertainty prior to the initiation of treatment. The present review aims to dissect current knowledge on real incidence, underlying pathophysiology, clinical features and predisposing factors related with the development of taxane-induced neuropathy.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.