Instrumentation on Multi-Scaled Scattering of Bio-Macromolecular Solutions

International Journal of Molecular Sciences

Benjamin Chu¹  Dufei Fang²  Yimin Mao² 

[1] Chemistry Department, Stony Brook University, Stony Brook, New York, NY 11794-3400, USA;

关键词: laser/X-ray scattering;    photon cross correlation spectroscopy;    size;    structure;    dynamics;   

DOI  :  10.3390/ijms160510016

来源: mdpi

【 摘 要 】

The design, construction and initial tests on a combined laser light scattering and synchrotron X-ray scattering instrument can cover studies of length scales from atomic sizes in Angstroms to microns and dynamics from microseconds to seconds are presented. In addition to static light scattering (SLS), dynamic light scattering (DLS), small angle X-ray scattering (SAXS) and wide angle X-ray diffraction (WAXD), the light scattering instrument is being developed to carry out studies in mildly turbid solutions, in the presence of multiple scattering. Three-dimensional photon cross correlation function (3D-PCCF) measurements have been introduced to couple with synchrotron X-ray scattering to study the structure, size and dynamics of macromolecules in solution.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.