High Prevalence of Vitamin D Deficiency in Pregnant Korean Women: The First Trimester and the Winter Season as Risk Factors for Vitamin D Deficiency

Nutrients

Rihwa Choi⁴  Seonwoo Kim²  Heejin Yoo³  Yoon Young Cho¹  Sun Wook Kim¹  Jae Hoon Chung¹  Soo-young Oh⁵ 

[1] Division of Endocrinology and Metabolism, Department of Medicine, Thyroid Center, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea; E-Mails:;Biostatistics Team, Samsung Biomedical Research Institute, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea; E-Mail:;Biostatistics and Clinical Epidemiology Center, Samsung Medical Center, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea; E-Mail:;Department of Laboratory Medicine and Genetics, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Korea; E-Mail:;Department of Obstetrics and Gynecology, Samsung Medical Center, Sungkyunkwan University School of Medicine, 81 Irwon-Ro, Gangnam-Gu, Seoul 135-710, Seoul, Korea

关键词: vitamin D;    pregnancy;    mass spectrometry;    Korea;    nutrition;   

DOI  :  10.3390/nu7053427

来源: mdpi

【 摘 要 】

We investigated the vitamin D status of Korean women during pregnancy and assessed the effects of vitamin D deficiency on two pregnancy outcomes; preterm births and the births of small for gestational age. We measured the serum 25-hydroxyvitamin D levels in 220 pregnant Korean women who were recruited prospectively and compared these levels with those of 500 healthy non-pregnant women. We analyzed vitamin D status according to patient demographics, season, and obstetrical characteristics; moreover, we also assessed pregnancy outcomes. The overall prevalence of vitamin D deficiency(<20 ng/mL) in pregnant women and healthy non-pregnant women was 77.3% and 79.2%; respectively; and the prevalence of severe vitamin D deficiency (<10 ng/mL) was 28.6% and 7.2%; respectively (p < 0.05). Vitamin D deficiency was more prevalent in the winter (100%) than in the summer (45.5%) in pregnant Korean women. A higher risk of vitamin D deficiency was observed in the first trimester than in the third trimester (adjusted OR 4.3; p < 0.05). No significant association was observed between vitamin D deficiency and any of the pregnancy outcomes examined. Further research focusing on the long-term consequences of vitamin D deficiency during pregnancy in Korean women is warranted.

【 授权许可】

CC BY   
© 2015 by the authors; licensee MDPI, Basel, Switzerland.